Information Bulletin GHB Analogs GBL BD GHV and GVL

GHB analogs : GBL BD GHV and GVL [National Drug Intelligence Center (U S ) ] Home WorldCat Home About WorldCat Help Search Search for Library Items Search for Lists Search for Contacts Search for a Library # Information bulletin (National Drug Intelligence Center This information is sometimes provided by witnesses who recall sinister comments made by an offender or it may be found in poisoning literature the offender accessed or ordered on the Internet Suspects who decide to procure poisons covertly may unintentionally reveal their identity when they purchase the poison or they may try to conceal their identity a sure sign of guilty knowledge

Gamma hydroxybutyrate (GHB) gamma butyrolactone

GHB can also be synthesised in vivo from its prodrugs or precursors GBL and 1 4-BD with GHB being the compound exerting the pharmacological effect (Carai et al 2002 Guidotti and Ballotti 1970 Roth et al 1966 Poldrugo and Snead 1984 Quang et al 2002a Quang et al 2002b Schneidereit et al 2000 Snead 1982 Snead et al 1989) 1 4-Butanediol a naturally occurring aliphatic

11-7-2003GHB analogs which include GBL BD GHV and GVL are drugs that possess chemical structures that closely resemble GHB The ingestion of any of these analogs produces physiological effects similar to the effects associated with GHB abuse--relaxation mild euphoria and drowsiness

^ Information Bulletin: GHB Analogs GBL BD GHV and GVL External links Erowid on GBL The paint stripper drug that kills BBC News October 7 2005 All About GHB a NIDA Neuroscience Consortium and OSPC Cutting Edge colloquium (27 June 2000 at the Doubletree hotel Rockville MD)

El GHB y sus metabolitos la γ-butirolactona (GBL) y el 1 4-butanediol (BD) producen deterioro del estado mental y alteraciones sensoriales Son sustancias psicotrpicas 1 7 6 Otros usos depresoras del sistema nervioso central que como tales se usan como una drogas ldicas [49]

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Criminal Poisoning: Clinical and Forensic Perspectives

This information is sometimes provided by witnesses who recall sinister comments made by an offender or it may be found in poisoning literature the offender accessed or ordered on the Internet Suspects who decide to procure poisons covertly may unintentionally reveal their identity when they purchase the poison or they may try to conceal their identity a sure sign of guilty knowledge

ガンマヒドロキシブチレート(GHB)へのおよび gamma hydroxybutyrate ghb dependence and withdrawal English Journal Biosynthesis of poly(3-hydroxybutyrate) and its copolymers by Yangia sp ND199 from different carbon sources Huu Phong T1 Van Thuoc D2 Sudesh K3

El GHB y sus metabolitos la γ-butirolactona (GBL) y el 1 4-butanediol (BD) producen deterioro del estado mental y alteraciones sensoriales Son sustancias psicotrpicas 1 7 6 Otros usos depresoras del sistema nervioso central que como tales se usan como una drogas ldicas [49]

2 Human pharmacology of GHB GBL and 1 4-BD Pharmacodynamics and pharmacokinetics of GHB is complex GBL and 1 4-BD are metabolised endogenously to GHB Their main subjective and behavioural effects result from this conversion While pathways of endogenous GHB are well elucidated the physiological and pharmacodynamic functions remain mainly

Accidental alcohol poisoning deaths contributing cause 1998 1 158 965 193 1997 1 104 931 173 1996 967 799 168 Annual average 1 076 898 178 Accidental alcohol poisoning deaths multiple causes 1998 1 458 1 210 248 1997 1 446 1 197 249 1996 1 275 1 045 230 Annual average 1 393 1 151 242 Source: Yoon Young-Hee et al "Accidental Alcohol Poisoning Mortality in the United States 1996–1998

This information is sometimes provided by witnesses who recall sinister comments made by an offender or it may be found in poisoning literature the offender accessed or ordered on the Internet Suspects who decide to procure poisons covertly may unintentionally reveal their identity when they purchase the poison or they may try to conceal their identity a sure sign of guilty knowledge

Information Bulletin: GHB Analogs GBL BD GHV and GVL Publication Date: August 2002 Document ID: 2002-L0424-003 Archived on: July 1 2009 This document may contain dated information It remains available to provide access to historical materials

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Gamma

Gamma-Butyrolactone Explained γ-Butyrolactone (GBL) is a hygroscopic colorless water-miscible liquid with a weak characteristic odor It is the simplest 4-carbon lactone It is mainly used as an intermediate in the production of other chemicals e g methyl-2-pyrrolidone In humans GBL acts as a prodrug for γ-hydroxybutyric acid (GHB) and it is used as a recreational CNS depressant with

1 4-BD • Aceburic Acid • Gabaculine • GBL • GABA • GABOB • GHB • GHV • GVL • Isovaleramide • Isovaleric Acid • Phenibut • Picamilon • Tiagabine • Valeric Acid • Valerenic Acid • Valnoctamide • Valproic Acid (Sodium Valproate / Valproate Semisodium) • Valpromide • Vigabatrin

GVL is metabolized by a lactonase to gamma-hydroxyvaleric acid (GHV 4-methyl-GHB gamma-methyl-GHB) with a higher maximum velocity (V m) than GBL (Figure 1) Compared to GHB the affinity of GHV for the GHB receptor is approximately two-fold lower than that of the endogenous substrate as determined in rat brain preparations ( 3 6 )

GHB analogs which include GBL BD GHV and GVL are drugs that possess chemical structures that closely resemble GHB These analogs also are sold illicitly as supplements for bodybuilding fat loss reversal of baldness improved eyesight and to combat aging depression drug

15-6-2007After ingestion 2 compounds the lactone and alcohol analogs γ-butyrolactone (GBL) and 1 4-butanediol (BD Figure Figure1) 1) are rapidly converted to GHB in the body For this reason these compounds are classified as pro-drugs of GHB 3 4 These analogs produce the same pharmacological and toxicological effects in humans and heavy abuse of them like that of GHB itself has led to

El GHB y sus metabolitos la γ-butirolactona (GBL) y el 1 4-butanediol (BD) producen deterioro del estado mental y alteraciones sensoriales Son sustancias psicotrpicas 1 7 6 Otros usos depresoras del sistema nervioso central que como tales se usan como una drogas ldicas [49]

GHB was initially sold as a safe bodybuilding and fat burning compound It is now also widely abused Miotto K A (2001) Gamma hydroxybutyrate (GHB) and gamma butyrolactone (GBL) withdrawal: five case studies J US Department of Justice (2002) GHB Analogs GBL BD GHV and GVL Information Bulletin National Drug Intelligence Center

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Gamma-hydroxybutyrate acid (GHB) a GABAB receptor agonist approved for treatment of narcolepsy impairs driving ability but little is known about doses and plasma concentrations associated with impairment and time course of recovery To assess effects of oral GHB (Xyrem) upon driving as measured by a driving simulator and to determine plasma concentrations associated with impairment

addiction after analogs another answered archives asset balanced baseball brussels bruxelles bulletin butyrolactone characteristic cleaner cleaning collection colorless committed common company contact contains create debentures designed electrafina encyclopedia europe exchange extraordinary focused focusing forget frequency gamco gamma general golden groupe holding hygroscopic

γ-Butyrolactone (GBL) l một chất lỏng khng mu khng tan trong nước c mi đặc trưng yếu N l đơn giản nhất 4-cacbon lacton N chủ yếu được sử dụng như một chất trung gian trong sản xuất cc ha chất khc v dụ methyl-2-pyrrolidone Ở người GBL hoạt động như một tiền chất cho axit γ-hydroxybutyric (GHB) v

BD: 1 4-butanediol tetramethylene glycol sucol-B butylene glycol Precursors for GBL which then become GHB GHV: gamma-hydroxyvalerate Valeric Acic methyl-GHB* Is its own separate metabolite however clinically is almost exactly like GHB GVL: gamma-valerolactone 4-pentanolide Precursor to GHV

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